The Effect of Maternal Vitamin D Intake on the Incidence of Nonspecific Respiratory Distress in Infants: A Randomized Clinical Trial

Background: Vitamin D deficiency is associated with respiratory problems in neonates. The late preterm or near-term neonates who have been admitted for tachypnea and fully recovered before 12 h are called non-specific distress syndrome (NRDS) cases. present study aimed to evaluate the effect of 25-hydroxy vitamin administration pregnant women at risk delivery on incidence NRDS their newborns. Methods: This single-blind clinical trial was performed mothers a gestational age 32–37 weeks were referred labor pains from February 20, 2021 June 29, Obstetrics Gynecology Department intensive care unit Ghaem Hospital, affiliated Mashhad University Medical Sciences, Iran. Within 72 premature delivery, dose 50,000 units 25 hydroxyvitamin injected intramuscularly intervention group. A sample containing 1.5 mL whole blood collected umbilical cord infant mother assess level D. Results: In study, there significant difference between two groups control terms infant’s weight (p = 001), 1-minute 0.027) 5-minute Apgar scores 0.001), maternal 0.004). However, results showed no statistically gender 0.673), type 0.299), 25-hydroxy(OH) 0.053), 0.805). Conclusions: single injection into prone birth over 31 gestation reduces transient Clinical Trial Registration: also registered Iranian Registration Center (IRCT20110807007244N7).